A Review Of The Positive And Negative Effects Of Cardiovascular Drugs On Sexual Function: A Proposed Table For Use In Clinical Practice

5 to 1 mg per pound per day, taken in a single dose or two divided doses.

They also were more likely to have decreased vaginal lubrication and trouble reaching orgasm. Due to this mechanism of action, calcium antagonists are not expected to cause sexual dysfunction [7]. What is erectile dysfunction? In a cross-over study comparing atenolol with valsartan, valsartan increased sexual activity significantly compared with atenolol (which significantly reduced sexual activity); however, these changes were not significant compared with placebo [11]. These medications target other hormone systems that also contribute to decreasing blood pressure, but don’t necessarily affect sexual function or cause impotence. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

In the Trial of Antihypertensive Interventions and Management (TAIM), erection-related problems worsened in 28 % of patients receiving chlortalidone, in 11 % of patients receiving atenolol and in 3 % of patients receiving placebo [15].

Erectile dysfunction may be an unpleasant condition that no one really wants to talk about, failing to acknowledge it won’t make the problem go away. The rate of blood flow into the penis can be measured along with an evaluation of problems with compression of the veins. Top therapy areas stories, your penis might feel cold to the touch. In a prospective observational study among 93 men it was suggested that ED following statin therapy is more likely in patients with severe endothelial dysfunction due to established cardiovascular risk factors, including age, smoking and diabetes [69].

It can cause injury or even death to a developing fetus when taken during the second and third trimesters of pregnancy, according to a black box warning on the drug’s label.

What is Your Next Step?

They come as news to me as a “seasoned” clinician – and they need to be known by all health professionals who treat BP. 5, 10, or 40/HCTZ 6. Other treatment options, vitaros should not be kept out of a fridge (2 to 8 celcius) for more than 3 days. Many people respond to intermittent therapy. 25b (n=144) (n=252) (n=144) (n=221) % % % % Cardiovascular bradycardia 0. Another smaller trial reported on by Chang et al.

Stress can also be a major factor because it may interfere with your brain sending signals to allow extra blood to flow to the penis. In clinical trials, patients treated with Diovan experienced occasional elevations of liver chemistries, according to the drug label. You and your healthcare provider might decide the best course of action is to try ED medication instead of switching antidepressants.

  • Kloner explained that cardiovascular disease and erectile dysfunction often go hand-in-hand.
  • Weight gain was more pronounced for women 60 and older who took the drug for less than one month or between two and five years and also took the drug Lyrica and had high cholesterol or asthma.
  • Keep this drug away from light.
  • Mean increases in serum triglycerides were observed in patients treated with bisoprolol fumarate and hydrochlorothiazide 6.
  • That might include erections that don’t last as long as you want or aren’t as firm as you’d like.
  • In one of the few studies addressing sexual function in women, thiazide diuretics may be associated with decrease in vaginal lubrication [34].
  • Therefore, this drug should only be used in pregnancy if clearly needed.

Hydrochlorothiazide Dosage

Taking the drug this way lowers your risk of an imbalance in your electrolytes. Some people are able to do that through lifestyle changes alone. There aren’t enough studies done in humans to show if the drug poses a risk to the fetus. Several drugs can produce erectile difficulties, but blood pressure drugs are near the top. The analysis included all patients who had a baseline measurement and at least one postbaseline measurement. Vacuum constriction devices, what should you do if your erection lasts too long? Be sure to avoid doing this when the weather is very hot or very cold.

Please note the date of last review or update on all articles. 1 Vascular hypertensive disorders (high-level group term). (6 mg/kg/day for 4 weeks) in vivo also were studied. The symptoms of erectile dysfunction include difficulty achieving an erection, trouble maintaining an erection and a reduced interest in sex. As the pressure builds, the blood becomes trapped in the corpora cavernosa, keeping the penis erect. Do not stop taking your medicines without speaking to your doctor first. For people with kidneys that don’t make enough urine:

The TOMHS trial (The Treatment Of Mild Hypertension Study), a 4-year follow-up, double-blind RTC in 557 men and 345 women, showed that chlortalidone at a dose of 15 mg/day may also be suspected to negatively affect sexual function in men [30].

There’s No Single Best Choice For Lowering Blood Pressure

This is the third piece in a five-part series, "Too High," created for those with high blood pressure and their family and friends. The number reporting overall sexual satisfaction increased from 7. An estimated 70% of men who have side effects from high blood pressure medicine stop taking it. 0 peripheral edema 0. Multiple studies have shown beneficial effects of ARBs on sexual function.

Q: My blood pressure medication, triamterene/hydrochlorothiazide, says I should stay away from sun exposure. Is there something else that is effective, but without the sun restrictions?

A prior history of cigarette smoking, heart attacks, strokes, and poor circulation in the extremities (for example, intermittent claudication or cramping in your leg[s] when you walk) suggest atherosclerosis as the cause of the erectile dysfunction. A 2020 study published in JAMA Internal Medicine concluded that a group of men who took Viagra were later diagnosed with melanoma more often than the group of men who did not take the drug. Also known as ED, erectile dysfunction is defined as the inability to achieve or maintain an erection firm enough for sex. What causes erection problems in one man may not affect another man. Are there other sexual side effects that might affect women as well? But it's possible that high blood pressure could affect a woman's sex life. The analyses of safety in the 14 studies included all enrolled patients. Vacuum constriction devices, he distinguishes between these two problems by measuring penile blood pressure. Hydrochlorothiazide oral tablet is used to treat high blood pressure, and swelling caused by heart failure, liver damage, and certain medications.

Ejaculation is a complex reflex process that involves the activation of alpha receptors in the prostate gland and seminal vesicles. You've chosen to add topics from the topic group to your selected topics. But the risks are encouragingly small. Your doctor may ask if you note erections at night or in the early morning. If you stop taking the drug suddenly, your swelling can increase and your blood pressure might increase rapidly. Medicines that reduce the testosterone level or block its effects are likely to reduce sex drive. Kochar MS et al. — — Thiazide diuretic use is associated with male sexual dysfunction but does not appear to adversely affect other aspects of quality of life.

It’s not clear whether those people might have experienced hair loss without taking the medication.


This study is typically performed after the injection of a chemical that causes the arteries to open up, a vasodilator (prostaglandin E1), into the corpora cavernosa in order to cause dilation of blood vessels and promote blood flow into the penis. Your best defense against health problems like this is to learn everything you can about it so you can tackle the problem at the root. Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension. The doctor will ask you about penile curvature and will examine the penis to see if there are any plaques (hard areas) palpable. This medication worked well at first, but caused an annoying dry cough. Some blood pressure medicines can also cause erectile dysfunction. It has largely fallen out of use in the UK, though in fact it is has a very good BP-lowering effect which is not dose-dependentA response to a drug which may be related to the amount received (i. What are the symptoms of erectile dysfunction?, the pituitary is also sometimes affected by small benign (non-cancerous) tumours that secrete prolactin, another hormone that can cause impotence. )Possible serious side effects include allergic reactions and rare instances of liver damage.

Hypertension is associated with severe erectile dysfunction. It isn’t known exactly how hydrochlorothiazide works. Natural remedies, it is an essential nutrient, found in foods such as chicken, pork and beef, dairy, tuna, salmon and anchovies. Arthralgia, muscle/joint pain, back/neck pain, muscle cramps, twitching/tremor. Men with heart conditions often develop erectile dysfunction (ED) and worry that their erection troubles are side effects of such drugs. It is important to discuss your prescribed medications, as well as over-the-counter medications and drugs of abuse such as opiates, alcohol, etc.

What if I think my medicine is affecting my sex life?

In many cases these elevations were attributed to underlying disorders, or resolved during continued treatment with bisoprolol fumarate. If you buy something through a link on this page, we may earn a small commission. Because of this, you should talk to your doctor before breastfeeding. Mesenteric arterial thrombosis and ischemic colitis.

No differences were seen between the use of ramipril, telmisartan or a combination of the two and there was no evidence for adverse effects of both treatments on erectile function [54]. You can’t take hydrochlorothiazide if your kidneys can’t make enough urine. Similar results were reported in a small group of women treated with losartan. There have been occasional reports of eosinophilia. Here is an overview of each category: For some women, this leads to a decrease in sexual desire or arousal, vaginal dryness, or difficulty achieving orgasm.

  • Our general interest e-newsletter keeps you up to date on a wide variety of health topics.
  • Since the Global Assessment Question (GAQ) was not gathered at 12 weeks in the study lasting 26 weeks, the GAQ results reported are from 13 studies.
  • It is possible that one of your blood pressure drugs is making it more difficult to maintain an erection (erectile dysfunction).
  • This is particularly true for beta blockers and diuretics (water pills) in men who experience erectile dysfunction.
  • Libido is also affected by your general emotional and physical health.
  • If you have high blood pressure, you usually don't have to live with a loss of sexual satisfaction.
  • Women should talk to their doctor if they experience these difficulties.

Alternative Names

It could be something as simple as a run away script or learning how to better use E-utilities, http: Symptoms of intermittent claudication of the lower extremities with exercise may suggest a vascular problem as a cause of the erectile dysfunction. Low potassium levels can lead to constipation, fatigue, muscle breakdown, and weakness. 5 percent to 62. It was noted, however, that ARBs were added on top of the previous multidrug regime in high-risk patients and thus conclusions regarding the effects of ARB monotherapy cannot be drawn [56].

0 Psychiatric insomnia 2. If you develop any sexual difficulties after taking your medication, don't suffer in silence. This means your child may need to take this drug every other day or for three to five days each week. All 14 of the studies excluded patients who, in the opinion of the investigator, were sildenafil nonresponders. This may be true for both benefits and harms. Hydrochlorothiazide may interact with other medications Hydrochlorothiazide oral tablet can interact with several other medications. In fact, a sexual issue may be the first symptom that raises the suspicion of underlying heart disease or peripheral artery disease. Can herbal remedies help or hurt erectile dysfunction? In order for us to best serve you and provide you with the best information, can you please tell us if you currently have health insurance?

Challenges For Men

Examples of these drugs include: No studies to date have isolated conclusively the effect of diuretic therapy on patient quality of life, and particularly on sexual dysfunction. Erectile dysfunction. Maintain a healthy weight., erectile dysfunction affects >30% of men between 40 and 70 years of age. A recent study by researchers at the University of Southern Denmark showed a connection between this medication and squamous cell carcinoma (SCC), the second most common type of skin cancer. This drug is cleared from your body by your kidneys.