Cotreatment with mevalonate inhibited the beneficial actions of rosuvastatin on aorta and corpus cavernosum. 4 points (95% CI 1. )Previous research has suggested, however, that statin therapy may lower testosterone levels.

In this evaluation, serum biochemical and lipid profile (total cholesterol, triglycerides, LDL and HDL cholesterol) analyses were performed at baseline and repeated at posttreatment weeks 6 and 12.

Another study evaluated the effects of adjunctive treatment with atorvastatin or the antihypertensive quinapril (an angiotensin converter enzyme inhibitor) in men with vasculogenic ED who were suboptimal responders to 100 mg of sildenafil. Men were excluded from the study if they had a history of cardiovascular disorders, listed in the study as either chest pain (angina) or heart attack (myocardial infarction), liver disorders, diabetes or a history of cancer. Read below for a full account of joe's experience with andro enhance. Statins are unlikely to be prescribed for erectile dysfunction in men without cardiovascular risk factors; at least in the near future.

Additionally, a trend toward improvement in IIEF‐5 with atorvastatin was significant. Main navigation, because penile vascular surgery is not recommended for aging males who have failed oral PDE5 inhibitors, ICI or IU therapies, implants are the next step for these patients. 88, 95%CI = 3. Review articles linked fibrates with erectile dysfunction. Functionally, their use results in reduction of hepatic synthesis of cholesterol, with a compensatory increase on the membrane of hepatocytes in the number of receptors with a high affinity for low‐density lipoprotein (LDL). The men were assessed by the international index of erectile dysfunction questionnaire, which asks about hardness of erections, penetration and confidence. The number of people buying a statin (such as Lipitor or Zocor) rose 88% from 2020 to 2020, from 15. The study found that erectile function scores rose by 4.

Men who suffer from erectile dysfunction (ED) may find that taking statin does not just help them reduce the amount of bad cholesterol in their body as the cholesterol lowering drug can also apparently help improve their erectile function.


The association between ED and statins was evaluated by calculating the reporting odds ratio (ROR) of exposure to each drug and its 95% confidence interval. Saltzman and colleagues ( 2020 ) in their study gave atorvastatin to 18 men with increased cholesterol as the only risk factor for organic ED diagnosed by abnormal nocturnal penile tumescence and rigidity testing. Common causes include heart disease, high cholesterol, high blood pressure, diabetes, obesity, tobacco use, depression and stress. Statins can help people with ED if the cause relates to high cholesterol. This study was of short duration (six weeks), so long-term outcomes of atorvastatin (Lipitor) to treat erectile dysfunction in men that have failed to improve on sildenafil (Viagra) are not known. More information about side effects is crucial to determining how safe the drug is when used to treat erectile dysfunction.

A review in the Journal of Sexual Medicine found that people who took statins were less likely to experience symptoms of ED than those who did not. What treatments are available for men with diabetes and erectile dysfunction? But the difference between statins was interesting. In penile tissue from diabetic animals, atorvastatin completely restored the diabetes‐induced hypersensitivity to Y‐27632 and prevented RhoA membrane translocation/activation.

  • “Make sure you have a doctor who listens to you.
  • Statins can not only lower cholesterol, but can improve erections, according to research presented at the European Society of Cardiology Congress in Rome last week.
  • In another study, Dadkhah and colleagues ( 2020 ) evaluated 131 patients with ED not responding to sildenafil.
  • You may not need Viagra or other drugs to get an erection.
  • 4 points—a 24.
  • Epidemiological studies have shown that elevated serum cholesterol and reduced high‐density lipoprotein (HDL) cholesterol levels are associated with an increased risk of erectile dysfunction (ED).

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(00001) showed that compared with placebo plus sildenafil, statins plus sildenafil clearly improved erectile function. Heart disease often occurs when there is a build-up of plaque in the arteries, which decreases blood flow to the heart, brain and rest of the body. Erectile dysfunction is a condition in which a person with a penis is unable to get or maintain an erection sufficient for sexual intercourse. Kostis will present the study, “Effect of Statins on Erectile Function,” on Saturday, March 29 at 1: This was a definite limitation of the study.

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Perhaps these results are another demonstration of the pleiotropic effects of statins on endothelial function. Results of this study showed that in the placebo group, impotence resolved in 2 men only after the study drug was stopped, whereas in the simvastatin group, impotence resolved in 14 men despite continued simvastatin treatment. Previous preclinical animal studies supported the improvement in both erectile function and eNOS by atorvastatin through the inhibition of Rho/Rho-kinase contractile mechanisms of the penis. Statins are often prescribed to reduce LDL cholesterol levels. Lower scores represent poorer sexual function. 0 years (1–21 years). Are there any studies concerning such drugs and high blood sugar levels?

Statins are commonly prescribed for people with ailments such as diabetes or heart disease, which can cause erectile dysfunction. It looks as if this is a real problem for a small number of men. Three of the studies compared statins with placebo. Where did the story come from? The paper reports on a small but well-conducted analysis of existing data into statin use and symptoms of erectile dysfunction (inability to obtain or maintain an erection). Investigators evaluated the consequences of cholesterol lowering with a statin, pharmacologic blood pressure reduction, and a combination of the two, on erectile function.

It is related to aspirin but is less likely to cause stomach irritation. Furthermore these results can be used as a patient education tool to encourage more patients, especially those with ED, to improve compliance with statin therapy. But discontinuation rates approach 50%, with most men citing lack of consistent efficacy as the cause for stopping. But then in 2020, another study was published in The American Journal of Medicine with patients taking statins for established cardiac disease or patients with the propensity for cardiac disease. Their mean age was 61 years, and they had high rates of smoking, ischaemic heart disease, and diabetes, and most were receiving antiplatelet therapy. In the study presented at the American College of Cardiology conference, experts performed a meta-analysis on 11 previous randomised, controlled studies on erectile dysfunction and statins.

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My cholesterol was elevated to 290, so my doctor prescribed atorvastatin. Secondary hypotheses: One prescription option that often is overlooked is the drug salsalate. And even that last one of muscle/joint pains has come under fire. Common causes of the condition include high cholesterol level, high blood pressure, tobacco use, stress and diabetes. Statins decrease the action of oxidized LDL on endothelial cells, which increases the activity of nitric oxide,* the main vasodilator in penile erection. 41 The antioxidant role of vitamin E was well established in earlier studies. NO synthase is responsible for NO formation in the endothelium.

More than 50 per cent of men over 40 experience some level of erectile dysfunction. The lowest prices of the international questionnaire indicate significant erectile dysfunction. The analysis of protein expression levels suggested elevation of RhoA and Rhokinase in obese diabetics and a lowering of Rho‐kinase II with statin treatment; then, the RhoA and Rho‐kinase II mRNA levels were significantly reduced in the rosuvastatin‐treated obese diabetic animals ( Wingard et al, 2020 ).

It is essential for several bodily functions, such as building new tissue and producing bile and sex hormones. Although cholesterol is essential, too much can cause a lot of health problems. OUTCOMES MEASURED: “The increase in erectile function scores with statins was approximately one-third to one-half of what has been reported with drugs like Viagra, Cialis or Levitra. Moreover, case reports and clinical trial evidence supported the contention that statins can also cause ED. Because the science on statins and sexual function is so inconclusive, Dr.

Eleven randomized controlled trials in which ED was assessed were identified from the 186 results of a search conducted by the authors of Medline, Web of Knowledge, Cochrane Database, and ClinicalTrials.

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A new study conducted by researchers from the Rutgers Robert Wood Johnson Medical School in New Jersey suggests that statins may be beneficial for men with erectile dysfunction, a condition that affects about 18 to 30 million men who are mostly more than 40 years old. The researchers found that statin has a significant impact on erectile dysfunction in men with high cholesterol levels and ED. Thus, activation of endothelial NO-synthase could raise the activation of guanylate-cyclase with a consecutive relaxation of smooth muscle cells in the penile arteries and the corpus cavernosum leading to an improvement of erectile function. During the study, none of the treatment groups were associated with a significant change in erectile function when compared to their respective placebo groups. Statins don’t touch any of these.

After 14 weeks of diabetes induction, basal and PDE5i‐elicited (intravenous mirodenafil, 1 mg/kg) erectile responses were assessed during cavernous nerve electrostimulation.

However, one study showed a statistically significant difference in erectile function in participants taking a statin vs. After adjustment for confounding factors (including body mass index and Progetto Cuore cardiovascular risk engine score), both total and calculated free testosterone levels were significantly lower in patients taking statins compared with the rest of the sample (hazard ratio [HR] = 0. )Millions of Americans are prescribed statins to prevent heart disease, but not everyone takes their medication as directed. Erectile dysfunction (ED) affects about 40 percent of men over 50 years old and is more common in men with cardiovascular risk factors. The results of the study were well reported in the Daily Mail. Author information, 36 Men with ED are at higher risk of angina, myocardial infarction, stroke, transient ischemic attack, congestive heart failure, and cardiac arrhythmias compared with men who do not have ED. Researchers said that the benefits of statins - which improve blood flow - had an impact on parts of the body far beyond the heart. For the comparison of statins plus sildenafil with placebo plus sildenafil, the mean IIEF‐5 (SMD = 3. )

One was a small, but randomised and double blind comparison of atorvastatin and placebo in 12 men with erectile dysfunction and who were taking sildenafil [6].

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Subgroup analyses revealed trends in the atorvastatin group to indicate that a change in the IIEF‐5 score is affected by age, severity of ED, and baseline serum levels of LDL. There was an average of 53 patients per study with a mean age of 57. But for our men with ED and dyslipidemia, adding atorvastatin to sildenafil can potentially provide both palliation and cure.

This was a blinded randomised controlled trial (RCT) comparing three interventions: Those on statins were more likely to have improved their score from moderate to mild dysfunction than those on no treatment. Data from randomised clinical trials showed no difference between simvastatin and placebo in the 4S study (37/1814 on simvastatin, 28/1803 on placebo), but erectile dysfunction was not reported in other randomised trials. Both fibrates and statins were independent predictors of erectile dysfunction with odds ratios of about 1. It is estimated that 18 million men in the United States experience erectile dysfunction. For example, someone with atherosclerosis may experience ED as a symptom of their condition. That just leaves the little problem of what to tell men when statins are needed.


None of the patients taking atorvastatin achieved a response of 5 to the IIEF‐5 questions, and none of the patients regained normal erectile function as defined by an IIEF‐5 score greater than 21 ( Dadkhah et al, 2020 ). In this study, 16 patients were receiving other drugs at the same time, and in 2 cases, the patients had diabetes mellitus (Carvajal et al, 2020). The results of a recent randomized, double‐blind, placebocontrolled clinical trial (Simvastatin treatment for erectile dysfunction trial) did not support the use of simvastatin as an erectogenic medication (Mastalir et al, 2020). Additionally, cavernosal tissue RhoA and Rho‐kinase expression levels were evaluated ( Wingard et al, 2020 ). This column, "What Matters," regularly appears in Internal Medicine News, a publication of Frontline Medical Communications. In addition, some patients taking atorvastatin achieved a response of 5 to some questions, but none of the participants regained normal erectile function (IIEF-5 score <22). Golomb said, patients who do notice sexual problems should talk to their doctors about whether the likely benefits of statins are worth the trade-off.

Participants in the RCT were men with erectile dysfunction who had previously received Viagra and failed to respond to treatment. While effective in many cases, a minority of men fail to respond to treatment with Viagra, often due to underlying problems with the blood vessels (endothelial dysfunction) that are connected to the penis. The goal of the treatment was to decrease total cholesterol to less than 200 mg/dL and LDL cholesterol to less than 120 mg/dL. Assessments were carried out before treatment, after treatment and every two weeks during treatment.

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Patients were asked to have sexual intercourse at least once per week, and they received medication for 12 weeks. It is a win-win. The SHIM score was 21 or less in 53 men (70%), which is indicative of ED. Major risk factors for erectile dysfunction include diabetes, smoking, drug and alcohol abuse, overweight, depression, stress, heart disease and certain medical treatments. Among the patients studied, 244 (7%) patients were being treated with statins. Full results from this study are being presented during the ACC 2020 but were released early via a special preconference press briefing, focused on consumer-interest news. The median age of patients was 56 years, the median induction period was 16 days, and the median recovery period was 27 days.

Further studies may be required to evaluate the responsiveness to sildenafil after atorvastatin intake. Atorvastatin decreased mean LDL cholesterol by 43% and resulted in a significant improvement of sildenafil efficacy in the domain score of 7. There are some limitations to this study, some of which are described by the authors:

That’s not to say there aren’t more serious potential complications with statin use. Other ed drugs, furthermore, due to comorbidities and multiple pathophysiologic changes in the old patient’s penis, vasculature, and nervous system, a fully rigid erection will be hard to be accomplished with the use of the oral pharmacotherapy alone [15]. In diabetic rats, atorvastatin ameliorated the erectile response to electrical stimulation of the cavernous nerve and normalized the sildenafil effect on erectile function, strongly decreased by diabetes. The objective of this selective EBM review is to determine whether or not HMG-CoA Inhibitors (Statins) are an effective treatment for erectile dysfunction (ED).

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Additionally, there was no difference in the IIEF score between the groups at follow‐up, although at the beginning, 26% of the patients of both groups presented with mild erectile dysfunction and 74% with moderate to severe erectile dysfunction. The researchers state that the increase seen was equivalent to about one-third of the improvement seen with drugs specifically designed to treat erectile dysfunction, such as the class of drugs known as phosphodiesterase 5 (the most famous of which is Viagra aka sildenafil. )However, despite this improvement, none of the men in the atorvastatin group had an erectile function score within the normal range at the six-week mark (a score less than 22 was considered to indicate erectile dysfunction). Although statins are not recommended as primary treatment for erectile dysfunction in men with normal cholesterol levels, this effect could improve compliance in hypercholesterolemic patients treated with statins. Clinical trials, when should you consider testosterone treatment for ED? The scores were then categorised into five categories – severe, moderate, mild-to-moderate, mild and no erectile dysfunction.

Examination of the 186 retrieved citations resulted in the selection of 11 randomized trials for inclusion in the meta‐analysis.

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The researchers then performed a meta-analysis to combine the results of the included studies. Moreover, in human fetal smooth muscle cells derived from the corpus cavernosum (hfPSMC), atorvastatin inhibited RhoA membrane translocation and ROCK activity, as well as RhoA‐dependent biologic functions like cell migration and cell proliferation. Almost all of these patients were taking statins (92%)—47% assumed β‐blockers and 28% diuretics (Kloner et al, 2020). The number of cases is small compared to the very widespread prescribing of lipid lowering drugs, especially statins.

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1%) had ED, whereas 431 (0. Finally, statins represent a stimulus for the release of endothelial progenitor cells, probably through the up‐regulation of metal‐loproteinase 9 ( Asahara et al, 1999 ; Figure ). Sildenafil is a phosphodiesterase type 5 inhibitor used to treat ED. It is especially a challenge when simple "fixes" do not work. Then, penile tissues were processed for molecular assessment. This study aims to investigate the relationship of erectile dysfunction with dyslipidemia and the possible impact of statins on erectile dysfunction (not receiving phosphodiesterase inhibitors). The absence of sexual activity was significantly associated with pretransplant sexual inactivity; age; cardiovascular diseases; and the use of statins, diuretics, anticoagulants, and antidiabetic drugs (Huyghe et al, 2020).

Side effects, according to the Mayo Clinic, include: The responsiveness to sildenafil was not evaluated at the end of intervention intake. WASHINGTON (March 29, 2020) — Statins are associated with a significant improvement in erectile function, a fact researchers hope will encourage men who need statins to reduce their risk of heart attack to take them, according to research to be presented at the American College of Cardiology’s 63rd Annual Scientific Session. Moderators, they ended up setting me up with a CPAP machine. None of the other clinical or biological data were significantly different (Bruckert et al, 1996).

The study included 100 male patients (aged 40–70 years) with unique risk factor dyslipidemia (none of them was receiving lipid-lowering treatment) and erectile dysfunction.

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However the relative risk for simvastatin (Zocor) was 1. The same cardiology congress that brought us statins for erectile dysfunction had Professor Giovanni de Gaetano’s study showing that a diet of fish, vegetables, nuts and oils can reduce early death from heart disease by 37%. These findings "may improve adherence to statin therapy. "

8 years and received statins for about 3. These are a class of drugs designed to temporarily boost the flow of blood to the penis during sexual stimulation. The reference lists of the retrieved studies were also investigated. About 90% of men recovered potency on statin withdrawal, and in some cases impotence appeared again on re-challenge. Contact us, a randomized, double-blind clinical trial to assess the impact of vardenafil ODT on duration of erection and its correlation with patients' and partners' sexual quality of life and duration of intercourse:. 8, whereas no significant change was observed in men receiving placebo. Design and method: The research included 100 men between the ages of 40 and 70 with erectile dysfunction and abnormal cholesterol. In other words, statins may be pretty powerful in improving sexual function, especially since the chief purpose of these drugs is to treat high cholesterol.


In a subsequent study, the validated Sexual Health Inventory for Men (SHIM) 5‐item questionnaire, based on the IIEF questionnaire, was administered to 76 men with chronic stable coronary artery disease during routine outpatient cardiology. Possible links to ED While ED isn’t a widely reported side effect of statins, researchers have explored the possibility. “The increase in erectile function scores with statins was approximately one-third to one-half of what has been reported with drugs like Viagra, Cialis or Levitra,” said John B. While these results are promising, the authors state that the statins were only between one-third and one-half as effective as phosphodiesterase-5 inhibitors. Erection was evaluated using the IIEF‐5 questionnaire and sexual satisfaction by the patient baseline treatment satisfaction status score. All of the studies were considered to be of high quality and used standardized ED assessments like the International Index of Erectile Function (IIEF). Patients were either treated with fluvastatin-sodium 80mg or placebo for 8 weeks.

Another study evaluated the frequency of ED after liver transplantation and discussed the potential risk factors. This test depended on visual examination, leading to higher error rates than other quantitative methods, which mainly use the Enzyme-linked immunosorbent assay technique. Download the piedmont now app, trying medicines that are injected or inserted into the penis. Although the methods used by the researchers were sound, the 11 randomised controlled trials included in the analysis only included a total 713 men. Their meta-analysis examined studies that compared statins (+/- sildenafil) with a placebo (+/- sildenafil).

The drug is often prescribed to help prevent stroke and heart attack but while statins are widely used as a cholesterol-reducing drug, it appears it also has versatile effects as to treat some other health conditions. We continue to identify technical compliance solutions that will provide all readers with our award-winning journalism. To yellow card reporting in different countries can be added the prospective cohort study.

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At baseline, the 2 groups had no significant differences, including IIEF‐5 scores, but after treatment, group 2 had a significantly higher postoperative IIEF‐5 score than group 1 at 6 months postoperatively. Scientists were surprised how successful the cholesterol-busting drugs were in helping to combat erectile dysfunction. Statins are used to control LDL Cholesterol in our bodies. Among men who had high cholesterol and erectile dysfunction – and who were taking statins – there was a statistically significant increase in erectile function, amounting to a 24. Additionally, maximum NO‐dependent nonadrenergic, noncholinergic nerve‐mediated relaxation of corpus cavernosum reduced by 25%–33% by diabetes was prevented by 75% and reversed by 71% after rosuvastatin treatment.

7; finally, Rigi‐Scan measurements showed a significant increased average penile rigidity at the base and tip after treatment with atorvastatin ( Saltzman et al, 2020 ). The complexity of female sexuality, the emotional and/or relational issues that may be contributing to her problem are assessed at this time. Case reports linked both fibrates and statins with erectile dysfunction in a small number of men. After a wash-out of 4 weeks, treatment will be switched (placebo/fluvastatin-sodium). Earlier clinical studies reported that atorvastatin showed a 7. Therefore, statins are supposed to be effective in the treatment of erectile dysfunction, especially in patients with cardiovascular risk-factors with underlying endothelial dysfunction. The study was carried out by researchers from Tanta University in Egypt and was funded by the same university. ” To order a copy, send a check for $16 to Graedons’ People’s Pharmacy, Dept.

After a 1‐month washout period, the patients received a single dose of atorvastatin, 10 mg/d, for 1 month; similarly, after a 1‐month washout period, atorvastatin, 10 mg/day, and sildenafil (a minimum of 2, 100‐mg tablets/wk) were administered for 1 month as a combination therapy. The large increase in the scores of question 2 and question 3 suggested a specific positive action of atorvastatin in improving penis firmness (question 2) and erection maintenance ability (question 3). Some docs are sceptical about the pills as they can cause debilitating side effects, including muscle pain. The pills are unlikely to be prescribed for the condition in those without cardiovascular risk factors, at least in the near future, the researchers said. Systematic reviews use explicit and reproducible methods to search for and assess studies for inclusion in the review. First published online: 4 points, from 14. In 2020/4, the WHO Uppsala Monitoring Centre had 144 reports of decreased libido, and 498 reports of impotence.

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The authors report that a major limitation of the study was that they did not assess whether sildenafil (Viagra) was effective as a follow-up treatment for erectile function after therapy with atorvastatin (Lipitor) or vitamin E. Testosterone is the primary male sex hormone, and it’s necessary for an erection to be achieved. The researchers studied databases of published literature to identify studies that had assessed the effects of statin therapy on erectile dysfunction. For more information, visit CardioSource. More recent experimental data concerning simvastatin reveals that the enhanced RhoA/Rho‐kinase pathway plays an anti‐erectile role and is associated with reduced response to type PDE5i inhibitor in diabetic animals. These effects were unrelated to the lipid-lowering activities of statins (Pleiotropic effects). There are also studies showing that reducing cardiovascular risk factors, like losing weight, can improve erectile function.